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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: GPR120 modulates epileptic seizure and neuroinflammation mediated by NLRP3 inflammasome

Fig. 4

GPR120 modulates epileptic seizure activity. a Graphic representation of the experimental timeline in the KA experiment. Mice were inject with GPR120-AAV-KD, CON-AAV-KD, GPR120-AAV-OE, CON-AAV-OE 3 weeks before KA injection (n = 6 in each group). b, d At the beginning of video monitoring, the latency period were reduce in the GPR120-AAV-KD group and increased in the GPR120-AAV-OE group compared with the Con-KD group and Con-OE group. c, e At the 24–30 days after KA injection in video monitoring, the Number of SRSs was increased in the GPR120-AAV-KD group and reduced in the GPR120-AAV-OE group compared with the Con-KD group and Con-OE group. f, j Representative LFPs in the four groups. g, k During 30 min, the number of SLEs and was increased in the GPR120-AAV-KD group and reduced in the GPR120-AAV-OE group compared with the Con-KD group and Con-OE group. h, l The total time spent in SLEs during the 30 min was increased in the GPR120-AAV-KD group and reduced in the GPR120-AAV-OE group compared with the Con-KD group and Con-OE group. i, m The duration of SLEs was not significantly changed between the groups. For the analysis, n = 6 for each group. Error bars represent the means ± SEM; *P < 0.05, **P < 0.01, ***P < 0.001 versus the Con-KD or Con-OE group, Student’s t test. ns not significant

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