Fig. 6

GPR120 affects proinflammatory cytokine production and NLRP3 inflammasome expression after SE. a, c, e The protein levels of IL-1β, IL-6 and IL-18 in hippocampal were increased after SE, and further increased by GPR120-AAV-KD. b, d, f SE-induced increases in IL-1β, IL-6 and IL-18 protein levels were markedly attenuated by GPR120-AAV-OE. g, i, k Increased the hippocampal protein levels of NLRP3, Caspase-1 and ASC after SE were markedly further increased by GPR120-AAV-KD. h, j, l Increased hippocampal protein levels of NLRP3, Caspase-1 and ASC after SE were markedly attenuated by GPR120-AAV-OE. For the analysis, n = 6 for each group. Error bars represent the means ± SEM; *P < 0.05, **P < 0.01, ***P < 0.001 versus the Control, Con-KD or Con-OE group, one-way analysis of variance (ANOVA), followed by Tukey’s test. ns not significant