Fig. 7

Caspase-1 inhibitor VX765 rescues the epileptic seizure activity, proinflammatory cytokine production and neuronal death caused by GPR120-AAV-KD. a, b Reduced latency period caused by GPR120-AAV-KD in epilepsy was rescued by VX765. c, d GPR120-AAV-KD induced increases in IL-1β, and IL-18 protein levels were markedly blocked by VX765. e VX765 has less effect on the protein level of IL-6. f The reduced number of surviving cells after SE attributed to GPR120-AAV-KD were rescued by VX765 (scale bar = 50 μm). For the analysis, n = 6 for each group. Error bars represent the means ± SEM; *P < 0.05, **P < 0.01, ***P < 0.001 versus the KA, KA + KD or KA + KD + VX765 group, one-way analysis of variance (ANOVA), followed by Tukey’s test. ns not significant