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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Prehabilitative resistance exercise reduces neuroinflammation and improves mitochondrial health in aged mice with perioperative neurocognitive disorders

Fig. 4

Resistance training inhibited inflammatory responses in the brain and peripheral organs of aged mice following surgery. a Relative mRNA levels of the inflammatory cytokines IL-1β, TNF-α, MCP-1 and the anti-inflammatory IL-10 in the hippocampus, muscle and liver after RE training. Data analyzed by unpaired Student’s t-test, n = 8. Data presented as mean ± SEM. *p < 0.05, **p < 0.01. b Relative mRNA levels of IL-1β, TNF-α, MCP-1 and IL-10 in the hippocampus at 24 h after surgery. Significant reduction in MCP-1 expression was observed in RE + Lap group. c Protein levels of IL-1β, TNF-α, MCP-1 and IL-10 in the hippocampus at 14 days after surgery. Significant reduction in MCP-1 expression was also observed in RE + Lap group. Data analyzed by one-way ANOVA with Tukey post hoc test, n = 8. Data presented as mean ± SEM. *p < 0.05

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