Skip to main content
Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Activation of locus coeruleus-spinal cord noradrenergic neurons alleviates neuropathic pain in mice via reducing neuroinflammation from astrocytes and microglia in spinal dorsal horn

Fig. 5

Activation of LC:SC for a week suppresses the activation of microglia and astrocyte in SDH. A Immunofluorescence images of microglia and astrocytes in the SDH in CCI mice. Scale bars = 100 μm. B, C Proportions of IBA1-positive area B and GFAP-positive area C in the SDH, which indicated that microglia and astrocyte (AS) were activated after CCI surgery. D Activation of LC:SC suppresses the activation of microglia and astrocyte in SDH. Scale bars = 100 μm. E, F Statistics of the proportion of IBA1 E- and GFAP F-positive area in the SDH, which indicated that one week of LC:SC activation can reverse the activation of astrocyte and microglia in CCI mice. Data are expressed as mean + SEM, n = 6, 5 slices for each mouse. *p < 0.05, **p < 0.01, ***p < 0.001. ns not statistically significant

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094