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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Activation of locus coeruleus-spinal cord noradrenergic neurons alleviates neuropathic pain in mice via reducing neuroinflammation from astrocytes and microglia in spinal dorsal horn

Fig. 6

Activation of LC:SC promotes anti-inflammatory cytokines and inhibits pro-inflammatory cytokines in SDH. A CCI increased TNF-α expression in SDH, whereas activation of LC:SC inhibited the expression of TNF-α. B CCI increased IL-1β expression in SDH, whereas activation of LC:SC inhibited the expression of IL-1β. C–H CCI increased the mRNA expression of TNF-α, IL-1β, CD68, IL-6, iNOS, and CD11b, whereas activation of LC:SC inhibited the expression of these mRNAs in the SDH of CCI mice. Yohimbine reversed LC:SC activation induced downregulation of these pro-inflammation mRNAs. I–L CCI inhibited the mRNA expression of Arg1, CD206, IL-4, and IL-10, whereas activation of LC:SC increased the expression of these mRNAs in the SDH of CCI mice. Yohimbine reversed LC:SC induced upregulation of these anti-inflammation mRNAs. Data are expressed as mean + SEM, n = 6. Statistical analyses consisted of one-way ANOVA tests followed by Tukey’s post hoc tests. *p < 0.05, **p < 0.01, ***p < 0.001. ns = not statistically significant

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Journal of Neuroinflammation

ISSN: 1742-2094