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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Activation of locus coeruleus-spinal cord noradrenergic neurons alleviates neuropathic pain in mice via reducing neuroinflammation from astrocytes and microglia in spinal dorsal horn

Fig. 7

Co-expression of TNF-α, IL-1β with IBA1 in the SDH. A Colocalization of TNF-α (red) and IBA1 (green) in the SDH following CCI. More colocalized microglia (yellow) can be seen in mice with CCI. B The representative images of double immunofluorescence staining showing that IL-1β (red) colocalized with IBA1 (green) in SDH. C, D Shown in relative number and in percentage, colocalization of TNF-α and IBA1 in CCI group increased compared to the Sham group. Compared with the CCI group, colocalization of TNF-α and IBA1 of the CCI + M3 + CNO group is reduced and can be reversed by yohimbine. E, F Colocalization of IL-1β and IBA1 in CCI group increased compared to the Sham group. Compared with the CCI group, colocalization of IL-1β and IBA1 of the CCI + M3 + CNO group is reduced and can be reversed by yohimbine. Scale bars = 100 μm. Data are expressed as mean + SEM, n = 6, 5 slices for each mouse. *p < 0.05, **p < 0.01, ***p < 0.001

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