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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: CXCL13 expressed on inflamed cerebral blood vessels recruit IL-21 producing TFH cells to damage neurons following stroke

Fig. 4

CXCR5+ CD4+ T cells and CXCL13+ vessels localize to human acute stroke infarcts. a Human brain section stained with hematoxylin and eosin (H&E) depicting immune cell cluster within the peri-infarct region of acute ischemic stroke patient brain. be Representative IHC staining of human acute stroke brain section with CD4 (green), CXCR5 (red), and DAPI (blue) (b), CD4 only (c), CXCR5 only (d), and negative control staining with secondary only and DAPI (e). f Human acute stroke tissue stained with H&E depicting an immune cell containing vessel within the brain. gj Representative IHC staining of human acute stroke brain section with CD31 (white), CXCL13 (red), and DAPI (blue) (g), CD31 only (h), CXCL13 only (i), and negative control staining with secondary only and DAPI (j). Scale bar = 50 μm

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