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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Microglia in depression: an overview of microglia in the pathogenesis and treatment of depression

Fig. 4

Schematic diagram of microglial activation involved in the pathogenesis of depression. Dysfunction of neuron–microglia interactions, particularly the CX3CL1-CX3CR1 and CD200-CD200R interactions, lead to behavioral and biochemical alterations. In addition, the most relevant markers of the NLRP3 inflammasome and neurogenesis used in the reviewed studies are indicated. We also included the generation of neuroactive kynurenine metabolites in depression disorders

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