Fig. 2
From: CEST MRI and MALDI imaging reveal metabolic alterations in the cervical lymph nodes of EAE mice
MRI of CNS-draining, superficial cervical LNs during EAE progression. A Disability score during the course of EAE. Arrows highlight days MRI was performed. B Visualization of the LNs using T2-weighted (T2-w) MRI. Quantification of (C) T2-w MRI and (D, E) CEST MRI signal intensity as disability progressed. Frequency ranges (± 0.2 ppm) whose average MTRasym-based CEST signals in EAE-induced mice (n = 8) and not in control mice (n = 4) significantly (p < 0.05) differed include (F) 0.4–6.0, (G) 1.6, (H) 3.2, and (I) 5.2 ppm. cLN cervical LN. *p < 0.05, **p < 0.01, ***p < 0.001 using ANOVA with Bonferroni post-hoc