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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: CEST MRI and MALDI imaging reveal metabolic alterations in the cervical lymph nodes of EAE mice

Fig. 3

MRI of CNS-draining, superficial cervical LNs at 14 DPI. Visualization of MR signal in (A, C) EAE-induced and (B, D) control (no MOG35-55) mice. A, B Overlay of average MTRasym-based CEST map (0.4–6.0 ppm) of LNs on T2-w image for anatomical reference. C, D Isolated T2-w and average MTRasym-based CEST maps at frequency ranges (± 0.2 ppm) with significant (p < 0.05 using ANOVA with Bonferroni post-hoc) alterations of signal in EAE-induced mice and not in control mice: 0.4–6.0, 1.6, 3.2, and 5.2 ppm

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