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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: The circadian clock protein Rev-erbα provides neuroprotection and attenuates neuroinflammation against Parkinson’s disease via the microglial NLRP3 inflammasome

Fig. 1

Aberrant diurnal Rev-erbα rhythm in the SN of MPTP-induced Mice. A Schematic diagram of expression profiles of Rev-erbα. After 7-day continuous injection of MPTP (25 mg/kg) or 0.9% saline, mice were euthanized at 4-h intervals throughout the day at ZT2, 6, 10, 14, 18, 22. B The mRNA level of Rev-erbα in the SN was quantified using real-time PCR. (*p < 0.05, two-way ANOVA test, interaction between time and genotypes). C The average values of Rev-erbα over the course of the day were calculated. (†††p < 0.001, two-way ANOVA test, interaction between genotypes). A representative western blot image (D) and the statistical graph (E) of Rev-erbα expression at ZT6 and ZT18 in the SN. The protein level of Rev-erbα was normalized to β-actin. (##p < 0.01, two-way ANOVA test). n = 3–5 for each time point. Data were presented as mean ± SEM

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