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Fig. 12 | Journal of Neuroinflammation

Fig. 12

From: The circadian clock protein Rev-erbα provides neuroprotection and attenuates neuroinflammation against Parkinson’s disease via the microglial NLRP3 inflammasome

Fig. 12

The mechanism underlying Rev-erbα /NF-κB/NLRP3 axis in MPTP-induced microglia neuroinflammation and dopaminergic impairment. MPTP upregulates the phosphorylation of NF-κB, then activates the NLRP3 inflammasome and promotes the release of inflammatory cytokines. These result in glial proliferation and microglial polarization, ultimately induced dopaminergic impairment. In addition, Rev-erbα-specific small molecule agonist SR9009 alleviates neuroinflammation and improves neurologic outcomes in the MPTP model

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Journal of Neuroinflammation

ISSN: 1742-2094