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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: DKK3 ameliorates neuropathic pain via inhibiting ASK-1/JNK/p-38-mediated microglia polarization and neuroinflammation

Fig. 3

Double-immunofluorescence of DKK3, Kremen-1, DVL-1, and NeuN, Iba1, GFAP in the spinal cord of sham and neuropathic pain rats. a Double-immunofluorescence of DKK3 and NeuN, Iba1, GFAP in the spinal cord of sham rats. b Double-immunofluorescence of DKK3 and NeuN, Iba1, GFAP in the spinal cord of SNI rats. c Double-immunofluorescence of Kremen-1 and NeuN, Iba1, GFAP in the spinal cord of sham rats. d Double-immunofluorescence of Kremen-1 and NeuN, Iba1, GFAP in the spinal cord of SNI rats. e Double-immunofluorescence of DVL-1 and NeuN, Iba1, GFAP in the spinal cord of sham rats. f Double-immunofluorescence of DVL-1 and NeuN, Iba1, GFAP in the spinal cord of SNI rats. g Histogram showed that DKK3 co-localization with NeuN, or Iba-1 was decreased in SNI rats (**p < 0.01, ****p < 0.0001 compared with sham group, n = 6 in each group). h Histogram showed that Kremen-1 co-localization with NeuN, or Iba-1 was decreased in SNI rats (**p < 0.01, ****p < 0.0001 compared with sham group, n = 6 in each group). i Histogram showed that DVL-1 co-localization with NeuN, or Iba-1 was decreased in SNI rats (**p < 0.01, ***p < 0.001 compared with sham group, n = 6 in each group)

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Journal of Neuroinflammation

ISSN: 1742-2094