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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: DKK3 ameliorates neuropathic pain via inhibiting ASK-1/JNK/p-38-mediated microglia polarization and neuroinflammation

Fig. 9

rDKK3 inhibited ASK1/JNK/p38 MAPK signaling pathway via Kremen-1 and DVL-1. a, b The expression level of ASK1 in the six groups had no significant change. rDKK3 reduced the increased p-ASK1 in neuropathic pain rats, while Kremen-1 siRNA or DVL-1 siRNA both reversed the down-regulated p-ASK1 caused by rDKK3 in neuropathic pain rats (***p < 0.001 compared with Sham group, ##p < 0.01 compared with SNI + Vehicle group, &&p < 0.01 compared with SNI + rDKK3 group, n = 6 in each group). c, d The expression level of JNK in the six groups had no significant change. rDKK3 reduced the increased p-JNK in rats with SNI, while Kremen-1 siRNA or DVL-1 siRNA both up-regulated the decreased p-JNK caused by rDKK3 in rats with neuropathic pain (****p < 0.0001 compared with Sham group, ####p < 0.0001 compared with SNI + Vehicle group, &&&&p < 0.0001 compared with SNI + rDKK3 group, n = 6 in each group). e, f The expression level of p38 in the six groups had no significant change. rDKK3 dampened the increased p-p38 in neuropathic pain rats, while Kremen-1 siRNA or DVL-1 siRNA both elevated the decreased p-p38 caused by rDKK3 in neuropathic pain rats (*p < 0.05 compared with Sham group, #p < 0.05 compared with SNI + Vehicle gro up, &p < 0.05, &&p < 0.01 compared with SNI + rDKK3 group, n = 6 in each group)

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