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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Superior control of inflammatory pain by corticotropin-releasing factor receptor 1 via opioid peptides in distinct pain-relevant brain areas

Fig. 6

Double-immunofluorescence staining of CRF-R1 (red fluorescence) A, D, G and POMC (green fluorescence) B, E, H (green fluorescence) E in the thalamus A–C and periaqueductal grey D–I of rat brain. A–C Coronal sections of the rat brain with hindpaw inflammation show that most of CRF-R1-positive neurons in the thalamus region express POMC, but few fibers contain CRF-R1 or POMC only. D–F Coronal sections of the rat brain with hindpaw inflammation show co-localization of CRF-R1 with POMC neurons in the periaqueductal grey, but few fibers contain CRF-R1 or POMC only. Bar = 20 µm, G–I Higher magnification of D–F. Bar = 40 µm

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Journal of Neuroinflammation

ISSN: 1742-2094