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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Superior control of inflammatory pain by corticotropin-releasing factor receptor 1 via opioid peptides in distinct pain-relevant brain areas

Fig. 7

Double-immunofluorescence staining of CRF-R1 (red fluorescence) A, D, G or CRF-R2 J–l with proopiomelanocortin (POMC) (B, K), β-endorphin (END) E and vasopressin H (green fluorescence) in the supraoptic area (SOA) of the rat hypothalamus. A–F Double-immunofluorescence staining of coronal sections of the rat brain with hind paw inflammation showing that CRF-R-immunoreactive neurons within SON overlap with the opioid peptide precursor POMC C or (F). Some neurons express CRF-R1 or POMC only. G–I Show the majority of CRF-R1-immunoreactive neurons residing in close vicinity, and rarely overlap (as indicated by yellow fluorescence) with vasopressin positive cells. J–L Show few scattered CRF-R2-immunoreactive neurons with only rare overlap with POMC-ir neurons. Bar = 20 μm

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