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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Superior control of inflammatory pain by corticotropin-releasing factor receptor 1 via opioid peptides in distinct pain-relevant brain areas

Fig. 8

Double-immunofluorescence staining of CRF-R1 (red fluorescence) A, D with proopiomelanocortin (POMC) B or β-endorphin (END) E (green fluorescence) in the Locus coeruleus (LC) of the rat brain. A–F Double-immunofluorescence staining of coronal sections of the rat brain with hind paw inflammation showing co-expression of CRF-R1 with POMC C or END F within LC. Some neurons express CRF-R1, POMC or END only. Bar = 20 µm for A–C. Bar = 40 μm for (D–F)

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