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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Persistent cortical and white matter inflammation after therapeutic hypothermia for ischemia in near-term fetal sheep

Fig. 5

Gitter cells in white matter regions and stratified by severity of myelin loss. Representative images of A ramified microglia in sham control, B amoeboid microglia in ischemia-normothermia, C gitter cells in ischemia-normothermia, D ramified microglia in ischemia-hypothermia. E Graph showing the number of gitter cells in the sham control (SC) (n = 8), ischemia-normothermia (IN) (n = 8) and ischemia-hypothermia groups (IH) (n = 8) in the intragyral white matter of the first parasagittal gyrus. *(p < 0.05) vs. sham control, ^(p < 0.05) vs. ischemia-normothermia. F Graph showing the proportion of gitter cells to the overall number of Iba1-positive cells in the intact area in sham control, lesion area and extensive diffuse area in ischemia-normothermia (IN) and intact area in ischemia-hypothermia (IH). *(p < 0.05) vs. sham control intact, ^(p < 0.05) vs. ischemia-normothermia intact, +(p < 0.05) vs. ischemia-normothermia lesion, ~(p < 0.05) vs. ischemia-normothermia extensive diffuse, Kruskal–Wallis one-way ANOVA for E and F. G Maximum intensity Z-projection of z-stack for gitter cell and MBP labeling. H Z-stack slice and associated orthogonal view of gitter cell shown in G containing MBP fragments. Scale bar for D and G = 20 µm

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