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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Targeting choroid plexus epithelium as a novel therapeutic strategy for hydrocephalus

Fig. 1

Physiology of choroid plexus epithelium. It transports water and ions, which are the major components of cerebrospinal fluid, and regulates its pH. These transport processes require the participation of transport proteins, such as aquaporin, which is involved in water transportation, and Na+-K+-ATPase, which is involved in the transport of various ions (mainly Na+ and K+). It also removes Pi through the protein PiT2, as well as other metabolic wastes. It is involved in the secretion and regulation of some neuropeptides. Serves as a transport channel for the delivery of certain drugs to the central nervous system. It is involved in the apoptosis pathways of other cells. During an inflammatory response, the connections between cells change, allowing some immune cells to pass through and participate in the response. CSF (cerebrospinal fluid), AQP (aquaporin), PIT2 (Pi transporter2), EGF (epidermal growth factor), VEGF (vascular endothelial growth factor), CNS (central nervous system), ICAM-1 (intercellular adhesion molecule-1), VCAM-1 (vascular cell adhesion molecule-1), Pi (inorganic phosphate)

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