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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Adaptation of prelimbic cortex mediated by IL-6/STAT3/Acp5 pathway contributes to the comorbidity of neuropathic pain and depression in rats

Fig. 1

SNI induced the mechanical allodynia and depression-like behaviors in rats. A Schematic timeline of the experimental procedure. B Paw withdrawal threshold on the ipsilateral hind paw was significantly decreased following SNI treatment in rats (n = 7 in each group, paired t-test, **p < 0.01 versus the sham group). C Immobility time of the FST was increased on weeks 5 after SNI (n = 7 in each group, unpaired t-test, ****p < 0.0001 versus the sham group). D Total distance of rats was examined in OFT for 15 min following SNI (n = 6 in each group, unpaired t-test, p = 0.9137 versus the sham group). E Distance of central zone (left) and outer zone (right) were examined in OFT for 5 min following SNI (n = 9 or 10 in each group, unpaired t-test, ****p < 0.0001 versus the sham group). F Representative rat trajectory map in the OFT. G Percentage of time and the percentage of entries in the open arms was significantly decreased in EPM on 5 weeks after SNI (n = 7 in each group, unpaired t-test, for time: *p = 0.0159 versus the sham group; for entries: **p = 0.0053 versus the sham group). H Percentage of time and the percentage of entries in the closed arms was examined in EPM following SNI (n = 7 in each group, unpaired t-test, for time: ***p = 0.0001 versus the sham group; for entries: *p = 0.0172 versus the sham group). I Representative trajectory map of EPM test for rats. Data are expressed as mean ± SEM

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