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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Adaptation of prelimbic cortex mediated by IL-6/STAT3/Acp5 pathway contributes to the comorbidity of neuropathic pain and depression in rats

Fig. 2

Activity and the excitability of pyramidal neurons in PrL on weeks 5 in the comorbidity of rats. A fALFF value in whole brain were examined by rs-fMRI on weeks 5 following SNI (n = 11 in each group). B Resting membrane potential of PrL pyramidal neurons was examined in naïve, sham and comorbidity group (n = 15 or 20 in each group, One-way ANOVA, F(2,47) = 20.93, ****p < 0.0001 versus the sham group). C Representative traces of action potential with injected current of 140 pA in both naïve, sham and comorbidity groups. D Action potential firing rate of pyramidal neurons was decreased in comorbidity rats (n = 15 or 20 in each group, Two-way ANOVA, ****p < 0.0001 versus the sham group). Data are expressed as mean ± SEM

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Journal of Neuroinflammation

ISSN: 1742-2094