Fig. 4
From: Factor VII, EPCR, aPC Modulators: novel treatment for neuroinflammation
The effects of FEAM on LPS-induced neuroinflammation in N9 microglia cell-line: A Cell proliferation: LPS treatment caused significantly higher cell proliferation, compared to control. LPS model cells, that were treated with FEAM, showed significantly lower proliferation compared to untreated LPS cells. N = 22–120. B aPC activity: LPS treatment caused significantly lower aPC activity, compared to control. FEAM treatment had no significant effect on aPC activity in LPS model cells. N = 23–118. C Thrombin activity: LPS treatment caused significantly higher thrombin activity, compared to control. FEAM treatment significantly decreased thrombin activity compared to untreated LPS cells. N = 20. Results are presented as mean ± SEM, *p < 0.05, **p < 0.01, ****p < 0.0001