Fig. 5
From: Factor VII, EPCR, aPC Modulators: novel treatment for neuroinflammation
The effects of FEAM on LPS-induced neuroinflammation in N9 microglia cell-line: A protein kinase B (pAKT) protein levels significantly increased following LPS treatment. This effect was partially prevented by FEAM. N = 4–6. B phosphorylated extracellular regulated kinase (pERK) protein levels significantly increased following LPS treatment and further increased following FEAM treatment. N = 4. C PAR1 protein levels were significantly reduced following LPS treatment and were partially recovered by FEAM. N = 6. D Tumor-necrosis factor α (TNF-α) protein levels significantly increased following LPS treatment. This increase was prevented by FEAM. N = 8–9. Results are presented as mean ± SEM, *p < 0.05, **p < 0.005, ****p < 0.0002