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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Factor VII, EPCR, aPC Modulators: novel treatment for neuroinflammation

Fig. 8

Activity and proteins present in the hippocampus of mTBI model: A Higher thrombin activity was found in the brain of mTBI group mice on days 1 and 3. No differences between the groups were found on days 30 and 104. N = 8–15. B No higher thrombin protein levels were found in mTBI mice brain p-mTBI. N = 3–11. C Higher aPC activity levels were found in mTBI and mTBI + FEAM mice brain 1-day p-mTBI. N = 15. D Higher aPC protein levels were found in mTBI mice brain 3- and 30-days p-mTBI. N = 3–11. D Higher PAR1 protein levels were found in mTBI + FEAM mice brain 1-day p-mTBI. Higher PAR1 protein levels were found in mTBI mice brain 30- and 104-days p-mTBI. N = 3–11. E Higher TNF-α protein levels were found in mTBI mice brain 3 days p-mTBI. Higher TNF-α protein levels were found in mTBI and mTBI + FEAM mice brain 30 days p-mTBI. N = 2–11. Results are presented as mean ± SEM, *p < 0.05, **p < 0.01, ****p < 0.0001

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