Fig. 9

Effect of rottlerin on the expression of C1q, IL-1β, and TNFα in the hippocampus of mice 6 days after TMT treatment. A Effect of rottlerin on C1q expression. Each value is the mean ± S.E.M. of 4 (Vehicle + Saline and Rottlerin + Saline) or 5 (Vehicle + TMT and Rottlerin + TMT) mice. B Effect of rottlerin on IL-1β and TNFα expression in the hippocampus. Each value is the mean ± S.E.M. of 3 (Vehicle + Saline and Rottlerin + Saline) or 4 (Vehicle + TMT and Rottlerin + TMT) mice. Square boxes in A indicate the region of interest for quantification. Veh, Vehicle. Sal, Saline. Rot, Rottlerin. ^*P < 0.05, ^**P < 0.01 vs. corresponding Saline; ^##P < 0.01 vs. Vehicle + Saline (two-way ANOVA followed by Fisher’s LSD pairwise comparisons test). Scale bar = 200 µm