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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Activating cGAS–STING axis contributes to neuroinflammation in CVST mouse model and induces inflammasome activation and microglia pyroptosis

Fig. 3

Time course expression of NLRP3, GSDMD and GSDMD-C in cerebral cortex tissues and cell localization of GSDMD after CVST. A Western blot assay of the temporal profiles of NLRP3, GSDMD, and GSDMD-C expressions from the injured cortex at 6 h, 1 d, 3 d, 7 d, and 14 d post-CVST. BD Quantitative analysis for western blot assay. Bars represent mean ± SEM. **P < 0.01 vs Sham group. n = 6 per group. E Immunofluorescent double staining showed the GSDMD mainly localized in the microglia/macrophage (IBA-1, B(a), as indicated by the white arrows) but rarely in astrocytes (GFAP, B(b)) and neurons (NeuN, B(c)) at 3 d after CVST. Scale bar = 50 um

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