Fig. 8

Effects of STING on NLRP3 inflammasome and pyroptosis as well as neuronal damage post-CVST. A Representative western blot images of STING, p-NF-κb p65, NF-κb p65, NLRP3, caspase-1 p20, pro-IL-1β, cleaved IL-1β, GSDMD, GSDMD-C at 3 days post-CVST. B Quantitative analysis of western blot assay. ^*P < 0.05, ^**P < 0.01. n = 6. C Representative microphotographs and quantitative analyses of TUNEL-positive cells (red). Scale bar = 50 μm. ^*P < 0.05, n = 5. D Typical microphotographs and quantitative analyses of FJC-positive cells (green). Scale bar = 50 μm. ^**P < 0.01, n = 5