Fig. 9From: Activating cGAS–STING axis contributes to neuroinflammation in CVST mouse model and induces inflammasome activation and microglia pyroptosisA schematic diagram displaying the pyroptosis and neuroinflammatory cascades on dsDNA recognition by microglia cGAS–STING axis during CVST. We demonstrated that suppression of dsDNA-sensing cGAS–STING pathway may exert neuroprotection and ameliorate the neuroinflammatory pathology of CVST, possibly by inhibiting NLRP3 inflammasome activation and GSDMD-mediated pyroptosis. In addition, concomitant oxidative stress may involve activation of cGAS and NLRP3 inflammasome through diverse mechanisms, ultimately contributing to the combustion of the neuroinflammatory process post-CVSTBack to article page