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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: Activating cGAS–STING axis contributes to neuroinflammation in CVST mouse model and induces inflammasome activation and microglia pyroptosis

Fig. 9

A schematic diagram displaying the pyroptosis and neuroinflammatory cascades on dsDNA recognition by microglia cGAS–STING axis during CVST. We demonstrated that suppression of dsDNA-sensing cGAS–STING pathway may exert neuroprotection and ameliorate the neuroinflammatory pathology of CVST, possibly by inhibiting NLRP3 inflammasome activation and GSDMD-mediated pyroptosis. In addition, concomitant oxidative stress may involve activation of cGAS and NLRP3 inflammasome through diverse mechanisms, ultimately contributing to the combustion of the neuroinflammatory process post-CVST

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