Table 2 The most significantly downregulated mRNAs in hBMECs upon infection
From: SARS-CoV-2 productively infects human brain microvascular endothelial cells
Gene symbol | Ensembl gene ID | log2(fold change) | p value | q value |
|---|---|---|---|---|
NEU1 | ENSG00000204386 | − 21.88265783 | 2.17E−08 | 1.76E−07 |
CHMP3 | ENSG00000115561 | − 5.362242755 | 0.000493786 | 0.001962402 |
GJB1 | ENSG00000169562 | − 5.101785064 | 0.001368014 | 0.004937517 |
CFAP47 | ENSG00000165164 | − 4.724579521 | 0.005709798 | 0.017747683 |
MGARP | ENSG00000137463 | − 4.503180663 | 0.010783266 | 0.031122636 |
CCDC187 | ENSG00000260220 | − 3.996799492 | 1.20E−06 | 7.63E−06 |
CHAT | ENSG00000070748 | − 3.913490411 | 3.62E−33 | 1.30E−31 |
LEFTY2 | ENSG00000143768 | − 3.808163847 | 6.57E−07 | 4.35E−06 |
novel.1068 | – | − 3.551248115 | 0.000551614 | 0.002160943 |
EXTL1 | ENSG00000158008 | − 3.265373003 | 0.001404158 | 0.005049692 |
OR2B6 | ENSG00000124657 | − 3.085358052 | 0.012758699 | 0.035990702 |
TXNIP | ENSG00000265972 | − 3.066511011 | 2.61E−255 | 1.08E−252 |
SERPINF2 | ENSG00000167711 | − 3.043253694 | 1.57E−198 | 4.88E−196 |
SLC2A2 | ENSG00000163581 | − 3.019859147 | 0.012528758 | 0.035401966 |
THSD7A | ENSG00000005108 | − 2.990344181 | 6.00E−08 | 4.59E−07 |
OR1F12 | ENSG00000220721 | − 2.971771113 | 1.57E−10 | 1.63E−09 |
H2AC7 | ENSG00000196866 | − 2.87703511 | 0.003118136 | 0.010338306 |
LCN12 | ENSG00000184925 | − 2.834977689 | 1.15E−06 | 7.32E−06 |
novel.19299 | – | − 2.832122052 | 9.66E−06 | 5.29E−05 |
H3C4 | ENSG00000197409 | − 2.772546205 | 1.60E−06 | 1.00E−05 |
CAPN3 | ENSG00000092529 | − 2.712469596 | 3.46E−05 | 0.000173351 |
H2BC8 | ENSG00000273802 | − 2.702182842 | 3.80E−07 | 2.62E−06 |
SCARA5 | ENSG00000168079 | − 2.635582038 | 5.34E−166 | 1.15E−163 |
FOXJ1 | ENSG00000129654 | − 2.605063889 | 0.01084363 | 0.031254005 |
SMTNL2 | ENSG00000188176 | − 2.554792408 | 0.000873797 | 0.003281935 |
CDH12 | ENSG00000154162 | − 2.525048622 | 3.71E−54 | 2.22E−52 |
SRGAP3 | ENSG00000196220 | − 2.482822207 | 1.21E−08 | 1.01E−07 |
ERP27 | ENSG00000139055 | − 2.475509651 | 0.006759849 | 0.020625759 |
DNAH6 | ENSG00000115423 | − 2.439137171 | 0.008656114 | 0.025631459 |
novel.774 | – | − 2.410152295 | 2.27E−44 | 1.08E−42 |