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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Anti-IgLON5 antibodies cause progressive behavioral and neuropathological changes in mice

Fig. 3

Dysfunction of memory-related neuronal oscillations in the CA1 of patient IgG-injected mice. A, B Schematic of the experimental design. Scale bar = 200 μm. C Time course of CA1 raw LFP from a mouse in the control or patient group exploring freely at day 7. D During novel object recognition task at day 7. The time “0” refers to the onset of an interaction event. Warmer colors indicate enhanced power. E Mean theta, beta, and gamma power while the mice explore the novel object at day 7. The patient IgG-injected mice show significantly lower gamma-band activity than does the healthy control IgG-injected mice (t = 4.941, df = 10, p = 0.0006; unpaired t-test). F Time course of CA1 raw LFP from a mouse in the control or patient group exploring freely at day 30. G During novel object recognition task at day 30. The time “0” refers to the onset of an interaction event. Warmer colors indicate enhanced power. H Mean theta, beta, and gamma power while the mice explore the novel object at day 30. The patient IgG-injected mice show significantly lower gamma-band activity than does the healthy control IgG-injected mice at day 30 (t = 6.269, df = 10, p < 0.0001, unpaired t-test). For CH, n = 6 per group. ***p < 0.001, ****p < 0.0001 versus control IgG group

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