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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Far infrared light irradiation enhances Aβ clearance via increased exocytotic microglial ATP and ameliorates cognitive deficit in Alzheimer’s disease-like mice

Fig. 4

Increased ATP production was involved in the FIR light-enhanced microglial Aβ phagocytosis. A Intracellular ATP of microglia under different conditions. B Intracellular ATP of microglia exposed to FIR light. Upon the FIR light treatment, C before Aβ phagocytosis, intracellular ATP of microglia treated with antimycin A or not, D Aβ phagocytosis of microglia treated with antimycin A or not, E after Aβ phagocytosis, intracellular ATP of microglia treated with antimycin A or not. Upon the treatment with antimycin A or not, F before Aβ phagocytosis, intracellular ATP of microglia cultured in medium containing glucose of 25 mM and 0.1 mM, respectively, G Aβ phagocytosis of microglia cultured in medium containing glucose of 25 mM and 0.1 mM, respectively, H after Aβ phagocytosis, intracellular ATP of microglia cultured in medium containing glucose of 25 mM and 0.1 mM, respectively. Data were means ± SEM, n = 6, *p < 0.05, **p < 0.01, ***p < 0.001. AA: antimycin A

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