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Table 1 Clinical characteristics of the SDAVF patients

From: Potential biomarkers of spinal dural arteriovenous fistula: C4BPA and C1QA

 

Discovery cohort (n = 8)

Validation cohort (n = 17)

Age (mean ± SD, year)

51.6 ± 14.9

59.3 ± 9.4

Sex (male, %)

75.0%

78.9%

Disease duration (median + IQR, Mon.)§

14.6 ± 9.5

9.9 ± 7.0

History of steroid therapy

25.0%

17.6%

Total protein of CSF (mean ± SD, mg/dl)

56.1 ± 24.5

MR imaging (positive, %)

  

Long T2 signal

75.0%

64.7%

Fluid-void

87.5%

94.1%

Fistula location by DSA

  

Cervical

5.9%

Thoracic

87.5%

70.5%

Lumbar

12.5%

23.6%

Combined score (CS, Mean ± SD)

  

Preoperation

8.8 ± 1.4

9.6 ± 3.5

Hospital discharge

8.5 ± 2.0, p = 0.5983

8.6 ± 3.0, p = 0.0370

The last follow-upØ

7.1 ± 3.8, p = 0.1428

6.4 ± 3.4, p = 0.0068

Worsen rate (%)£

12.5%

17.6%

Improvement rate (%)¥

71.4%

76.5%

Recovery rate (median + IQR, %)$

36.4% (3.6%, 50%)

15.6% (− 3.1%, 46.0%)

  1. §: duration of the disease was the time from onset to last hospitalization. †: A total of five patients suffered acute exacerbation after the corticosteroid therapy, which varied in class, dose, and duration, but drug withdrawal occurred over 1 month before the last hospitalization. Ø: The last follow-up was 1 year in the discovery cohort and 6 months in the validation cohort. : A two-tailed paired t test was performed to compare the scores pre- and postoperation. £: "Worsen" was defined as the follow-up CS increasing over 1 point compared to the preoperative score. ¥: "improvement" was defined as the follow-up CS decreasing over 1 point compared to the preoperative level. $: the individual recovery rate (%) = (preoperative CS − postoperative CS)/preoperative CS × 100%. IQR: interquartile range. "-" refers to no data available