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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Gut microbiota depletion by antibiotics ameliorates somatic neuropathic pain induced by nerve injury, chemotherapy, and diabetes in mice

Fig. 2

The continuous feeding of ABX alleviates CCI-induced thermal hyperalgesia but not mechanical allodynia. A–C Pre-depletion of gut microbiota, two weeks earlier than CCI treatment. D–F The continuous feeding of ABX starting simultaneously with CCI treatment. G–I The continuous feeding of ABX starting two weeks after CCI treatment when the thermal hyperalgesia and mechanical allodynia had been established. B, E Two-way ANOVA with Dunnett multiple comparison test **p < 0.01 SPF + CCI versus SPF, ##p < 0.01 SPF + CCI versus ABX + CCI. C, F **p < 0.01 versus SPF. H *p < 0.05 **p < 0.01 versus SPF + CCI. Numbers of animals included in each of the groups: A–C, n = 6 in SPF, n = 10 in SPF + CCI, n = 5 in ABX, n = 7 in ABX + CCI); E, F, n = 10 in SPF and ABX, n = 12 in SPF + CCI and ABX + CCI; H, I: n = 10 in SPF + CCI, n = 11 in ABX + CCI

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