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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: Gut microbiota depletion by antibiotics ameliorates somatic neuropathic pain induced by nerve injury, chemotherapy, and diabetes in mice

Fig. 9

16S rRNA sequencing profiles of the gut microbiota in SPF control mice and those with CCI and ABX treatment as well as restoration of gut microbiota. A Timeline of experimental design. B α-diversity (Shannon) of the composition of microbiota. One-way ANOVA with Dunnett multiple comparison, **p < 0.01 versus SPF; ##p < 0.01 versus ABX + CCI. C PCA analysis showing the major differences in the composition of microbiota. D Observed operational taxonomic units (OUTs) of microbiota. Two-way ANOVA with Tukey multiple comparison **p < 0.01 versus SPF + CCI, #p < 0.05 versus ABX + CCI. E Stacked bar-chart showing gut microbiota composition at family level. F Specific bacteria genus abundance that corelated with the restoration of pain hypersensitivity. Oral fecal microbiota gavage increased the relative abundance of Akkermansia genus (upper), Desulfovibrionaceae genus (middle), and Bacteroides genus (bottom). One-way ANOVA with Tukey multiple comparison ##p < 0.01 versus ABX + CCI. Number of animals: n = 6 in SPF, n = 5 in SPF + CCI, n = 5 in ABX + CCI, and n = 4 in ABX + CCI Conv

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