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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Positive interaction between GPER and β-alanine in the dorsal root ganglion uncovers potential mechanisms: mediating continuous neuronal sensitization and neuroinflammation responses in neuropathic pain

Fig. 4

RNA-Seq identifies mRNA expression changes in the dorsal root ganglion (DRG) of spared nerve injury (SNI) rat models and G15-treated rats, and inflammation occurs synchronously. A Venn diagram showing the overlapping of DEGs in DRG from Sham, SNI, SNI + G15 rats. B Heatmap illustrations of hierarchical clustering analysis of differentially expressed mRNAs (DEmRNAs) in DRG from sham, SNI, SNI + G15 group rats. C Volcano plots of DEmRNAs in the DRG of SNI + G15 group rats vs. SNI rats. Red points refer to upregulated DEGs and green points refer to downregulated DEGs, and grey spots indicate non-DEGs. D Bubble plots showing the top 20 significant pathways for upregulated DEmRNAs. Downregulated DEmRNAs. E, F KEGG pathway analysis of DEmRNAs. E, The top 22 significant biological processes, molecular functions, and cellular components of upregulated DEmRNAs. F, The top 19 significant biological processes, molecular functions, and cellular components of downregulated DEmRNAs. The dotted line indicates a p value < 0.001. G Protein expression levels of IL-1β and IL-6 in DRG from Sham, SNI, SNI + G15 rats. (n = 3, one-way ANOVA, **p < 0.01 versus sham; ##p < 0.01 versus SNI)

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Journal of Neuroinflammation

ISSN: 1742-2094