Skip to main content
Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Positive interaction between GPER and β-alanine in the dorsal root ganglion uncovers potential mechanisms: mediating continuous neuronal sensitization and neuroinflammation responses in neuropathic pain

Fig. 5

Metabolomics reveals that β-alanine metabolism is involved in post-spared nerve injury (SNI) GPER upregulation. A Box charts of the relative trends of top nine metabolites involved in the important metabolic pathways that were identified. Data are expressed as the mean ± SEM. B Heatmap of metabolites in DRG of rats in the sham, SNI, and SNI + G15 groups. Red indicates higher levels and blue indicates lower levels. C Venn diagram showing the overlapping of metabolites in DRG from Sham, SNI, and SNI + G15 rats based on pairwise comparison. The number represents the number of metabolites that change together in a pairwise comparisons. D Metabolite sets enrichment overview analysis. E PPI network analysis of metabolites involved in GPER response-related pathways in the DRG of SNI model rats. Metabolites related to pain response-related pathways identified by GO and KEGG analyses were subjected to PPI network analysis. A larger circle reflects more interactions and vice versa

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094