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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Positive interaction between GPER and β-alanine in the dorsal root ganglion uncovers potential mechanisms: mediating continuous neuronal sensitization and neuroinflammation responses in neuropathic pain

Fig. 8

Mechanistic diagram of GPER/β-alanine mediating neuronal sensitization and neuroinflammation in modulating neuropathic pain. Schematic illustration demonstrates that the upregulation of GPER in neurons and microglial cells in the DRG signals to sensory neurons upon peripheral nerve damage, inducing an increase neuronal β-alanine while positively promoting GPER. Their combined effect further activates iNOS, IL-1β and IL-6 and regulates GABAα2. The positive GPER/β-alanine interaction in the DRG uncovers enhances pain sensation and promotes chronic pain development

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