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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Neuroinflammation in the anterior cingulate cortex: the potential supraspinal mechanism underlying the mirror-image pain following motor fiber injury

Fig. 5

Effects of DREADD-hM3Dq and hM4Di on ACC CX3CL1 protein levels and the mechanical paw withdrawal thresholds. A Behavioral test paradigms are shown on the top and representative western blotting for bilateral ACC CX3CL1 in the mice injected with DREADD-Gq or DREADD-Gi are shown below. B The injection site of virus carrying hM3Dq-, hM4Di-mCherry or mCherry in contralateral ACC. C Quantification of bilateral CX3CL1 in the mice injected with DREADD-Gq and DREADD-Gi, respectively. *p < 0.05, ***p < 0.001 versus mCherry control groups (n = 3 mice/group, two-way ANOVA). D Compared to the mCherry control mice, DREADD-hM3Dq induced significant decrease of threshold in ipsilateral hind paws of normal mice (left); DREADD-hM4Di reversed the SNI-induced decrease of ipsilateral threshold (right). *p < 0.05 versus mCherry control groups (n = 6 mice/group, multiple t tests)

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Journal of Neuroinflammation

ISSN: 1742-2094