Fig. 2

Expression of RAGE, MR, HMGB1, and ATP1α3 in brain parenchyma with inflammatory changes, and the vascular expression of RAGE, MR, and NFκB in rats harboring IAs prone to rupture. A Elevated expression levels of RAGE, MR, and HMGB1 in the brain parenchyma adjacent to the Lt PCA prone to rupture. B Reduced expression level of ATP1α3 and the increased expression levels of Iba-1 and S100B in the brain parenchyma adjacent to the Lt PCA. C Vascular expression levels of RAGE, MR, and NFκB at the Lt PCA. At 6 weeks after IA induction or at the time of rupture within 6 weeks, the area adjacent to the Lt PCA prone to rupture (A, B) and the vascular wall (C) were harvested. Data are expressed as the mean ± standard deviation (n = 5). *p < 0.05 vs. the sham/SD rats by the Dunnett’s test