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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: An imbalance between RAGE/MR/HMGB1 and ATP1α3 is associated with inflammatory changes in rat brain harboring cerebral aneurysms prone to rupture

Fig. 3

Elevated mRNA level of RAGE and the decreased mRNA level of ATP1α3 associated with the brain water-free sodium accumulation in OVX/HT/HSD rats. A Brain water and Na+ accumulation in the oophorectomized hypertensive rats fed a high-salt diet (OVX/HT/HSD) and the sham-operated rats fed a standard diet (sham/SD). B Elevated mRNA level of RAGE was inversely correlated with the decreased mRNA levels of ATP1α2 and ATP1α3. In the brain at 4 weeks after IA induction, the brain water and Na+ accumulation and the mRNA levels of RAGE, MR, ATP1α2, and ATP1α3 were analyzed. Data are expressed as the mean ± standard deviation (n = 6). *p < 0.05 vs. the sham/SD rats by the Dunnett’s test

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Journal of Neuroinflammation

ISSN: 1742-2094