Fig. 2

Exacerbated EAE disease is not caused by cIAP2^−/− bone-marrow derived cells. A Clinical score for EAE in WT → WT, (n = 4), cIAP2^−/− → WT (n = 11), WT → cIAP2^−/− (n = 9) and cIAP2^−/− → cIAP2^−/− (n = 6) bone-marrow chimera; mean ± SEM, *p < 0.05, **p < 0.01; Two-way ANOVA. B, C Antigen uptake and D, E MHC II expression in WT (n = 3) and cIAP2^−/− (N = 3) bone-marrow-derived macrophages treated with IFNγ and AF647 OVA antigen; mean ± SD, T-test; *p < 0.05. Grey peaks represent wildtype macrophages without IFNγ treatment