Fig. 7

Suppressing astrocytes in mPFC of susceptible mice reversed depressive-like behaviors in HFD mice. A To assess the behavioral changes among different mice model, social interaction was performed under aggressor present and absent. B The anxiety behaviors of mice were evaluated by open-field test and elevated plus-maze, and C depressive behaviors of mice were investigated by tail suspension test, forced swim test, and sucrose preference test. To detect neuronal activities in mPFC, sIPSC and sEPSC (D) were recorded, and frequency and amplitude were calculated (E and F). (*p < 0.05, **p < 0.01 compared with saline-treated mice)