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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Delayed administration of nafamostat mesylate inhibits thrombin-mediated blood–spinal cord barrier breakdown during acute spinal cord injury in rats

Fig. 3

Thrombin activity and expression pattern of thrombin, PAR1 and MMP9 after SCI. A Illustration describing the experiment design for temporal expression of thrombin and its downstream proteins. B Representative line chart of temporal thrombin activity after SCI (2 h, 8 h, 12 h, 24 h, 3 d, 7 d). C Quantitative analysis of thrombin activity (data shown as mean ± SEM, one-way ANOVA with Tukey's post hoc test, *P < 0.05, **P < 0.01, ***P < 0.001, n = 3). D Representative western blot image of the temporal expression after SCI (2 h, 8 h, 12 h, 24 h, 3 d, 7 d) of thrombin, PAR1 and MMP9. The expression level of each protein was normalized by GAPDH. E Quantitative analysis of the temporal expression of MMP9, thrombin and PAR1 normalized by GAPDH (data shown as mean ± SEM, one-way ANOVA with Tukey's post hoc test, P value of MMP9 was shown as *, thrombin as #, and PAR1 as &, *P < 0.05, **P < 0.01, ***P < 0.001 vs. the SCI group, n = 3)

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