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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Delayed administration of nafamostat mesylate inhibits thrombin-mediated blood–spinal cord barrier breakdown during acute spinal cord injury in rats

Fig. 8

Nafamostat inhibited macrophage and neutrophil infiltration after SCI. A Immunofluorescence image of CD31 (red) and CD68 (green) in posterior horn of spinal cord at 3 dpi. Cell nuclei were stained with DAPI (blue). Scale bar = 50 μm. B Immunofluorescence image of CD31 (red) and MPO (green) in posterior horn of spinal cord at 3 dpi. Cell nuclei were stained with DAPI (blue). Scale bar = 50 μm. C Illustration describing the image acquisition area in this figure. Fluorescent photos were acquired at the posterior horn of the spinal cord. D Quantitative analysis of the amount of CD68+ cells in posterior horn of spinal cord at 3 dpi. All data represent mean ± SEM. *P < 0.05 and **P < 0.01 vs. injury (one-way ANOVA with Tukey's post hoc test, n = 3). E Quantitative analysis of the amount of MPO.+ cells in posterior horn of spinal cord at 3 dpi. All data represent mean ± SEM. ***P < 0.001, ****P < 0.0001 vs injury (one-way ANOVA with Tukey's post hoc test, n = 3)

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