Fig. 3From: Targeted BRD4 protein degradation by dBET1 ameliorates acute ischemic brain injury and improves functional outcomes associated with reduced neuroinflammation and oxidative stress and preservation of blood–brain barrier integritydBET1 reduces infarct volume after stroke. A Representative images of TTC stained 1-mm thick coronal brain slices of vehicle- and dBET1-treated mice at 48 h after tMCAO. Quantitative analyses of the overall infarct volume (B) or detailed infarct area of each brain slice (C) were performed. The cortex, striatum, and hemisphere infarct volumes B were significantly reduced in the dBET1 group than the vehicle-treated control group. Analysis of infarct area per slice shows that the decreases in infarct volume are seen throughout the hemisphere. Veh: n = 14; dBET1: n = 13. *P < 0.05, **P < 0.01. Veh, vehicle; TTC, 2,3,5-triphenyl-2H-tetrazolium chlorideBack to article page