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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Transient post-operative overexpression of CXCR2 on monocytes of traumatic brain injury patients drives monocyte chemotaxis toward cerebrospinal fluid and enhances monocyte-mediated immunogenic cell death of neurons in vitro

Fig. 1

CXCR2 expression in peripheral monocytes is transiently upregulated in traumatic brain injury (TBI) patients after surgery. A (Left) Flow cytometry results of constitution of classical (CD14++CD16−), intermediate (CD14++CD16 +), and non-classical (CD14lowCD16+) monocyte subsets in peripheral blood of TBI patients after surgery. (Right) Flow cytometry results of CXCR2 expression on peripheral classical monocytes of patients with TBI or crainoplasty. Isotype control is shown as gray filled histogram and CXCR2 is shown as open histogram. B The expression profile of ΔMFI value of CXCR2 in peripheral CD14+ monocytes around surgery of patients with TBI or crainoplasty. C ΔMFI value of CXCR2 in peripheral CD14+ monocytes of patients with TBI or crainoplasty before surgery. The dashed line represents average ΔMFI value of CXCR2 in monocytes of healthy controls (HC, n = 29). **P < 0.01, determined by Mann–Whitney tests. D ΔMFI value of CXCR2 on peripheral CD14+ monocytes of patients with TBI or crainoplasty after surgery. *P < 0.05, **P < 0.01, determined by Mann–Whitney tests. E CXCR2 ΔMFI value and intracranial pressure (ICP) of patients with TBI after surgery. The dot plot represents the CXCR2 ΔMFI value and the column represents ICP. Data are presented as mean with SEM

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Journal of Neuroinflammation

ISSN: 1742-2094