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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Transient post-operative overexpression of CXCR2 on monocytes of traumatic brain injury patients drives monocyte chemotaxis toward cerebrospinal fluid and enhances monocyte-mediated immunogenic cell death of neurons in vitro

Fig. 3

TBI serum and CSF promotes CXCR2 expression in peripheral monocytes. A Typical flow cytometry results of CXCR2 surface expression on peripheral monocytes educated by TBI/non-TBI serum (left) or CSF (right). Mono represents peripheral monocytes alone, not being educated by serum or CSF. B Percentage of CXCR2+ cells in peripheral monocytes alone, or educated by TBI/non-TBI serum or CSF. **P < 0.01, determined by paired t tests. C ΔMFI value of CXCR2 in peripheral monocytes alone, or educated by TBI/non-TBI serum or CSF. **P < 0.01, determined by paired t tests. D mRNA levels of CXCR2 in peripheral monocytes educated by TBI/non-TBI serum or CSF. Data are presented as fold change of CXCR2 mRNA expression in treated ones to that in untreated ones. **P < 0.01, determined by paired t tests. E mRNA levels of p65 in peripheral monocytes educated by TBI/non-TBI serum or CSF. Data are presented as fold change of p65 mRNA expression in treated ones to that in untreated ones. **P < 0.01, determined by paired t tests. F Typical flow cytometry results of CXCR2 surface expression on peripheral monocytes educated by TBI serum (left) or CSF (right), with/without dexamethasone (DXM) treatment. G mRNA levels of CXCR2 in peripheral monocytes educated by TBI serum or CSF, with/without DXM treatment. Data are presented as fold change of CXCR2 mRNA expression in serum/CSF-treated ones to that in untreated ones. **P < 0.01, determined by paired t tests. Data are presented as mean with SEM

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