Fig. 8From: The immunometabolite S-2-hydroxyglutarate exacerbates perioperative ischemic brain injury and cognitive dysfunction by enhancing CD8+ T lymphocyte-mediated neurotoxicitySchematic illustrating novel mechanism underlying S-2HG-mediated perioperative ischemic brain injury. Perioperative risk factors trigger an aberrant metabolic accumulation of S-2HG in peripheral CD8+ T cells and thus enhance the activation of CD8+ T cells. During the ischemic stroke event, migration and adhesion of activated peripheral CD8+ T cells to disrupted BBB and brain parenchyma will further exacerbate ischemic brain injury and neurological dysfunctionBack to article page