Fig. 4

Increase in the pathogen-specific antibody index (AI) for IgG after successful treatment of CNS infections. In a 66-years old patient with Varicella zoster virus (VZV) cerebellitis at the first lumbar puncture, when VZV DNA was detected in CSF by nucleic acid amplification (PCR), the VZV-AI was not elevated. After successful treatment with aciclovir, the VZV-PCR became negative. The patient almost completely recovered, whereas the VZV-AI steadily rose [86]. Reproduced with kind permission of Elsevier HCM—Health Content Management